Public health and molecular epidemiology of age-related diseases
Team 1 – INSERM U1167 – Lille University – CHU Lille – Institut Pasteur de Lille
Our team works on aging-related diseases and on ischemic heart disease and cerebrovascular disease (Stroke) in particular. These diseases constitute major public health problems in aging populations, cardiovascular disease being the leading cause of death worldwide. Our main objective is to increase our level of knowledge of cardiovascular diseases through descriptive and analytical epidemiology approaches and the analysis of massive national health data. We monitor and analyze the trends of these diseases and of their risk factors, both environmental and genetic. We rely in particular on two morbidity registries, created respectively in 1985 for ischemic heart disease and in 2008 for stroke, which exhaustively monitor the occurrence of cases of these diseases on a daily basis. We are also developing analytical epidemiological studies on the determinants of these trends in close collaboration with the biological resources center of the Institut Pasteur de Lille (BRC IPL). For both diseases, specific epidemiological studies are carried out. These include (i) local recruitment of individuals in the north of France and (ii) collaboration and involvement in national, European and international consortia (iii) use of massive data from the National System of Health Data. We are also interested in the search for genetic determinants of the main known vascular risk factors such as obesity and lung disease in the context of vascular risk, inflammation and air pollution.
- We evaluated the long-term temporal trends (1986-2013) of the prevalence of cardiovascular risk factors, of estimated risk of coronary heart disease and of mortality in the urban community of Lille using the Lille ischemic heart disease registry and four cross-sectional studies (1986, 1995, 2006, 2011 – age 40-64, n = 4538). In men, the age-standardized prevalence fell from 70% to 42% for hypertension, from 71% to 58% for dyslipidemia and from 44% to 24% for smoking. The prevalence of overweight increased from 60% to 65%. In women, the prevalence decreased from 56% to 34% for hypertension and from 60% to 42% for dyslipidemia. The prevalence of smoking (17%) and overweight (50%) remained stable. At the same time, the observed coronary mortality rate fell by 2.6% in men and by 2.8% in women. This decrease was correlated with the decrease in the average fatal coronary disease risk, estimated over 10 years with a coronary risk equation i.e. a decrease of 2% per year for men and of 1.6% for women. These data indicate that primary prevention has made a significant contribution to reducing coronary heart disease mortality (Clement et al. (2017). Arch Cardiovasc. Dis. 110 :689) https://pubmed.ncbi.nlm.nih.gov/28958407/).
- Our participation in the NCD-RisC consortium through the general population samples MONICA, MONA LISA and ELISABET, resulted in several new publications including one describing the evolution of the trajectories of the height and the body mass index different across countries, among children and adolescents between 1985 and 2019 (Lancet 2020; 396:1511, https://pubmed.ncbi.nlm.nih.gov/33160572/).
- Geographical variations in cardiovascular disease rates have been linked to individual air pollutants. We assessed the relationship between exposure to multiple air pollutants and the incidence of coronary heart disease (CHD) in a general population sample. In the single pollutant analysis, PM10, NO2, cadmium, copper, nickel, and palladium were significantly associated with CHD rates. Multiple air pollution was associated with an increased risk of CHD. Single pollutants reflecting road traffic pollution were the most strongly associated with CHD. Our present results are consistent with the literature data on the impact of road traffic on the CHD risk in urban areas (Oscelli et al. (2020). Sci. Total. Environ. 714 : 136608) ; https://pubmed.ncbi.nlm.nih.gov/32018947/).
CRCN Inserm, group leader
ORCID number : 0000-0001-6983-2364
PU-PH, Univ Lille
ORCID number : 0000-0001-9088-234X
ORCID number : 0000-0002-0411-684X
MCU-PH, Univ Lille
ORCID number : 0000-0002-2398-0596
PU-PH, Univ Lille
ORCID number : 0000-0002-0848-0091
Roberto GONZALEZ SANCHEZ
CDD, Univ Lille
Kotseva K, De Bacquer D, Jennings C, Gyberg V, De Backer G, Rydén L, Amouyel P, Bruthans J, Cifkova R, Deckers JW, De Sutter J, Fraz Z, Graham I, Keber I, Lehto S, Moore D, Pajak A, Wood D.
EUROASPIRE Investigators. Adverse lifestyle trends counter improvements in cardiovascular risk factor management in coronary patients.
J Am Coll Cardiol. 2015; 66(14):1634-1636.
Debette S, Kamatani Y, Metso TM, Kloss M, Chauhan G, Engelter ST, Pezzini A, Thijs V, Markus HS, Dichgans M, Wolf C, Dittrich R, Touzé E, Southerland AM, Samson Y, Abboud S, Béjot Y, Caso V, Bersano A, Gschwendtner A, Sessa M, Cole J, Lamy C, Medeiros E, Beretta S, Bonati LH, Grau AJ, Michel P, Majersik JJ, Sharma P, Kalashnikova L, Nazarova M, Dobrynina L, Bartels E, Guillon B, van den Herik EG, Fernandez-Cadenas I, Jood K, Nalls MA, De Leeuw FE, Jern C, Cheng YC, Werner I, Metso AJ, Lichy C, Lyrer PA, Brandt T, Boncoraglio GB, Wichmann HE, Gieger C, Johnson AD, Böttcher T, Castellano M, Arveiler D, Ikram MA, Breteler MM, Padovani A, Meschia JF, Kuhlenbäumer G, Rolfs A, Worrall BB; International Stroke Genetics Consortium, Ringelstein EB, Zelenika D, Tatlisumak T, Lathrop M, Leys D, ; the CADISP group, Amouyel P, Dallongeville J.
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.
Nat Genet. 2015; 47(1):78-83.
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, …(215)…, Kathiresan S.
Exome-wide association study of plasma lipids in >300,000 individuals.
Nat Genet. 2017; 49(12):1758-1766.
Malik R, …(14)…, Amouyel P, …(407)…, Dichgans M; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STARNET; BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGASTROKE Consortium.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Nat Genet. 2018; 50(4):524-537.
Meirhaeghe A, Montaye M, Biasch K, Huo Yung Kai S, Moitry M, Amouyel P, Ferrières J, Dallongeville J.
Coronary heart disease incidence still decreased between 2006 and 2014 in France, except in young age groups: Results from the French MONICA registries.
Eur J Prev Cardiol. 2020; 27(11):1178-1186.
Registry ; Risk factors ; Epidemiology ; Public Health ; Genetic factors ; Coronary heart disease ; Stroke ; Obesity ; Lung function
Inserm researcher, group leader
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