A recent study published in the journal Nature Communications. reveals that the association between type 2 diabetes and high blood pressure is not only explained by lifestyle, but also by a complex genetic predisposition. The teams at Professor Philippe Froguel (INSERM U1283, CNRS UMR 8199, EGID, Univ/CHR Lille & Imperial College London) and Inga Prokopenko (University of Surrey, UK) analyzed 1304 independent genetic profiles associating 2 type diabetes et hypertensionResearchers have highlighted the diverse biological origins of the risk of developing type 2 diabetes and hypertension. Several distinct biological mechanisms are involved, some of which affect metabolism. (insulin deficiency, excess body fat) and others not (thyroid dysfunction)These results could allow for the early identification of individuals at high risk of serious complications such as stroke, heart failure, and kidney disease. They also pave the way for more personalized prevention and care, while highlighting the importance of environmental factors.
Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity
Pascat V, Zudina L, Maurin L, Ulrich A, Maina JG, Demirkan A, Balkhiyarova Z, Pupko I, Sharhorodska Y, Pattou F, Staels B, Kaakinen M, Khamis A, Bonnefond A, Munroe P, Froguel P*, Prokopenko I*
Common Nature2026 Feb 9;17(1):1446. doi: 10.1038/s41467-025-67449-2.
