A breakthrough in the understanding of neurodegenerative diseases.

Many neurodegenerative diseases are caused by the aggregation of highly flexible proteinsThese cells do not adopt a well-defined three-dimensional structure under normal conditions. To combat neurodegenerative diseases, it is important to understand the movements of these cells. individual atoms within these protein sequences. Spectroscopy by nuclear magnetic resonance is a powerful analytical tool for studying protein dynamics. This technique is difficult to implement for highly flexible proteins. The team at Dr. Davy Sinnaeve (Integrative Structural Biology, CNRS UMR 9031, Univ Lille) has developed a new approach, called SNIPERThis allows for the precise analysis of this type of protein. This innovation will deepen our understanding of neurodegenerative diseases at the molecular level.

Fast Ultra-Selective ¹H-¹⁵N 1D NMR Spectroscopy Unlocks Atom-Resolved Dynamics of Low-Complexity Protein Regions.
Adamski, W., Levy, GR, Cantrelle, F.-X. and Sinnaeve, D.
Angew. Chem. Int. Ed. 2026, e19206. doi: /10.1002/anie.202519206.

UMR9031 “Integrative Structural Biology (BSI)”
University of Lille – CNRS – Pasteur Institute of Lille