Our scientific papers
It is by the quality of scientific publications that the work of researchers is evaluated. These publications in international journals such as Nature, Nature Genetics, the Lancet, PLoS One, PLoS Medicine, Gut, the New England Journal of Medicine… are a reflection of the excellence of the production.
Bibliometrics, including a quantitative assessment of impact factors in prestigious journals, reflect the interest of the scientific community in the findings which are thus taken up and cited. Bibliometrics assesses research activity by applying statistical methods to scientific publications (bibliography of articles, signatures of articles, keywords and authors, etc.). It makes it possible to measure the scientific production and the notoriety of a researcher, a laboratory, an establishment, a country or a field of research.
- Interplay of physical activity and genetic variants of the endothelial lipase on cardiovascular disease risk factorsCONCLUSIONS: LIPG polymorphisms were significantly associated with CVD risk factors in European adolescents. Interestingly, alleles of these polymorphisms were associated with a better cardiovascular profile in physically active adolescents only. High physical activity may reduce the development of CVD, modulating its genetic risk. Read more »
- High incidence of postoperative infections after pancreaticoduodenectomy: A need for perioperative anti-infectious strategiesCONCLUSION: Patients undergoing pancreaticoduodenectomy experience a high rate of postoperative infections, often involving bacteria from perioperative bile culture when positive, with no preventive effect of an adequate preoperative antibiotic prophylaxis. Increased postoperative complications in patients with bile colonization may render necessary a perioperative antibiotic treatment targeting bile microorganisms. Further prospective… Read more »
- Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesisAlzheimer's disease (AD) is the most common form of dementia, currently affecting 35 million people worldwide. Apolipoprotein E (APOE) ε4 allele is the major risk factor for sporadic, late-onset AD (LOAD), which comprises over 95% of AD cases, increasing the risk of AD 4-12 fold. Despite this, the role of… Read more »
- Influenza infection impairs the gut's barrier properties and favors secondary enteric bacterial infection through reduced production of short-chain fatty acidsAlong with respiratory tract disease per se, viral respiratory infections can also cause extrapulmonary complications with a potentially critical impact on health. In the present study, we used an experimental model of influenza A virus (IAV) infection to investigate the nature and outcome of the associated gut disorders. In IAV-infected… Read more »
- Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart DiseaseTranscatheter aortic valve implantation (TAVI) is effective in older patients with symptomatic severe aortic stenosis, while the indication has recently broadened to younger patients at lower risk. Although thromboembolic and bleeding complications after TAVI have decreased over time, such adverse events are still common. The recommendations of the latest 2017… Read more »
- Changes in the Human Gut Microbiota Associated With Colonization by Blastocystis sp. and Entamoeba spp. in Non-Industrialized PopulationsHuman gut microbial communities are mainly composed of bacteria, but also include fungi, viruses, archaea, and protozoa, whose role in the gut ecosystem has only recently begun to be recognized. For example, humans colonized by Blastocystis (a gut protozoan with controversial pathogenicity) host a more diverse bacterial microbiota than individuals… Read more »
- Decrease of IL-5 Production by Naive T Cells Cocultured with IL-18-Producing BCG-Pulsed Dendritic Cells from Patients Allergic to House Dust MiteThe only currently available anti-tuberculosis vaccine, Bacillus Calmette-Guérin (BCG), has been reported to also protect against unrelated diseases, including inflammatory diseases such as allergic asthma. Recombinant BCG strains that produce IL-18 have been shown to enhance Th1 responses over non-recombinant BCG and to reduce IL-5 production and bronchoalveolar eosinophilia in… Read more »
- Editorial for the Special Issue: Epidemiology, Transmission, Cell Biology and Pathogenicity of CryptosporidiumThe apicomplexan parasite Cryptosporidium represents a major public health problem in humans and animals by causing self-limited diarrhea in immunocompetent individuals and life-threatening disease in immunocompromised hosts [...]. Read more »
- The Path to New Pediatric Vaccines against PertussisWhooping cough, or pertussis, mostly caused by Bordetella pertussis, is a respiratory disease that affects all age groups, but severe and fatal pertussis occurs almost exclusively in young children. The widespread use of whole-cell and, more recently, of acellular vaccines has substantially reduced the disease incidence. However, it has not… Read more »
- A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in MiceCombining amoxicillin with the immunostimulatory toll-like receptor 4 agonist monophosphoryl lipid A (MPLA) represents an innovative approach for enhancing antibacterial treatment success. Exploiting pharmacokinetic and pharmacodynamic data from an infection model of Streptococcus pneumoniae infected mice, we aimed to evaluate the preclinical exposure-response relationship of amoxicillin with MPLA coadministration and… Read more »