C’est à la qualité des publications scientifiques que l’on évalue le travail des chercheurs. Ces publications dans des revues internationales comme Nature, Nature Genetics, the Lancet, PLoS One, PLoS Medicine, Gut, the New England Journal of Medicine… sont le reflet de l’excellence de la production. La bibliométrie, incluant une évaluation quantitative des facteurs d’impact dans les revues prestigieuses, reflète l’intérêt de la communauté scientifique pour les découvertes qui sont ainsi reprises et citées.
La bibliométrie évalue l’activité de la recherche en appliquant des méthodes statistiques aux publications scientifiques (bibliographie des articles, signatures des articles, mots-clés et auteurs…). Elle permet de mesurer la production scientifique et la notoriété d’un chercheur, d’un laboratoire, d’un établissement, d’un pays ou d’un domaine de recherche.
- Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal MethylomeCONCLUSIONS: Our study reveals the potential complexity of the epigenetic transmission between mothers with GDM and their offspring, likely determined by not only GDM exposure but also other factors indicated by maternal epigenetic status, such as maternal metabolic history. Lire la suite »
- Pulmonary Hypertension in Patients with Common Variable ImmunodeficiencyCONCLUSION: PH is a possible complication of CVID whose pathophysiological mechanisms, while still unclear, would be due to the inflammatory nature of CVID. CVID-associated PH presents as precapillary PH with multiple possible causes, acting in concert in some patients: a portal hypertension, a pulmonary vascular remodeling, sometimes a pulmonary parenchymal… Lire la suite »
- Rational and Design of the SIMULATOR Study: A Multicentre Randomized Study to Assess the Impact of SIMULation-bAsed Training on Transoesophageal echocardiOgraphy leaRning for Cardiology ResidentsIntroduction: Simulation-based training in transesophageal echocardiography (TEE) seems promising. However, data are limited to non-randomized or single-center studies. To assess the impact of simulation-based vs. traditional teaching on TEE knowledge and performance for medical residents in cardiology. Materials and Methods: Nationwide prospective randomized multicenter study involving 43 centers throughout France… Lire la suite »
- Alcohol Intake and Total Mortality in 142,960 Individuals from the MORGAM Project: a population-based studyCONCLUSIONS: In comparison with lifetime abstainers, consuming less than 1 drink per day (nadir at 5 gr/d) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than 2 drinks per day was associated with an increased risk of total, cardiovascular and… Lire la suite »
- History of heart failure in patients with coronavirus disease 2019: Insights from a French registryCONCLUSIONS: History of heart failure in patients with COVID-19 was associated with a higher risk of in-hospital death or orotracheal intubation. These findings suggest that patients with a history of heart failure, particularly heart failure with preserved ejection fraction, should be considered at high risk of clinical deterioration. Lire la suite »
- Common variants in Alzheimer's disease and risk stratification by polygenic risk scoresGenetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n… Lire la suite »
- Collagen Suprafibrillar Confinement Drives the Activity of Acidic Calcium-Binding Polymers on Apatite MineralizationBone collagenous extracellular matrix provides a confined environment into which apatite crystals form. This biomineralization process is related to a cascade of events partly controlled by noncollagenous proteins. Although overlooked in bone models, concentration and physical environment influence their activities. Here, we show that collagen suprafibrillar confinement in bone comprising… Lire la suite »
- Airway Administration of Flagellin Regulates the Inflammatory Response to Pseudomonas aeruginosaExcessive lung inflammation and airway epithelium damage are hallmarks of human inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity provides protection against pathogens while reducing lung-damaging inflammation. However, the mechanisms underlying innate immunity-mediated protection in the lung remain mysterious, in part because of the lack of… Lire la suite »
- Biochemical composition of Phleum pratense pollen grains: A reviewThe Poaceae family is composed of 12,000 plant species. Some of these species produce highly allergenic anemophilous pollen grains (PGs). Phleum pratense pollen grains (PPPGs) emerged as a model for studies related to grass allergy. The biochemical composition of allergenic PGs has not yet been fully described despite potential health… Lire la suite »