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Directeur :
CNRS UMR 8090
Institut Pasteur
de Lille
Université de Lille 2
Rattachée à l'IFR 114
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| Maladies cardiovasculaires, métaboliques et neurodégénératives |
Diabète de type 2. Diabète à début précoce. Obésité. Bioinformatique. Génotypage. Séquençage. Gènes candidats
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Badii R, Bener A, Zirie M, Al-Rikabi A, Simsek M, Al-Hamaq AO, Ghoussaini M, Froguel P, Wareham NJ.
Lack of association between the Pro(12)Ala polymorphism of the PPARgamma2 gene and type 2 diabetes mellitus in the Qatari consanguineous population.
Acta Diabetol, 2007, Sep 6. |
Bell CG, Meyre D, Petretto E, Levy-Marchal C, Hercberg S, Charles MA, Boyle C, Weill J, Tauber M, Mein CA, Aitman TJ, Froguel P, Walley AJ.
No contribution of angiotensinconverting enzyme (ACE) gene variants to severe obesity : a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases.
Eur J Hum Genet, 2007, 15(3):320-327. |
Bouatia-Naji N, Vatin V, Lecoeur C, Heude B, Proenca C, Veslot J, Jouret B, Tichet J, Charpentier G, Marre M, Balkau B, Froguel P, Meyre D.
Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity.
BMC Med Genet, 2007, 8:44. |
Cauchi S, El Achhab Y, Choquet H, Dina C, Krempler F, Weitgasser R, Nejjari C, Patsch W, Chikri M, Meyre D, Froguel P.
TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups : a global meta-analysis.
J Mol Med, 2007, 85(7):777-782. |
Cauchi S, Meyre D, Choquet H, Deghmoun S, Durand E, Gaget S, Lecoeur C, Froguel P, Levy-Marchal C.
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population.
BMC Med Genet, 2007, 8:37. |
Cauchi S, Vaxillaire M, Choquet H, Durand E, Duval A, Polak M, Froguel P.
No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or
neonatal diabetes mellitus in French white subjects.
Diabetologia, 2007, 50(1):214-216. |
Chu WS, Das Sk, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, Mccarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E, Elbein SC.
Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-Diabetic Traits.
Diabetes, 2007, 56(3):856-862. |
Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougneres P, Kovacs P, Marre M, Balkau B, Cauchi S, Chevre JC, Froguel P.
Variation in FTO contributes to childhood obesity and severe adult obesity.
Nat Genet, 2007, 39(6):724-726. |
Dina C, Meyre D, Samson C, Tichet J, Marre M, Jouret B, Charles MA, Balkau B, Froguel P.
Comment on «A Common Genetic Variant Is Associated with Adult and Childhood Obesity».
Science, 2007, 315(5809):187. |
Fairbrother UL, Tanko LB, Walley AJ, Christiansen C, Froguel P, Blakemore AI.
Leptin Receptor Genotype at Gln223Arg is Associated with Body Composition, Bone Mineral Density and Vertebral Fracture in Postmenopausal Danish Women.
J Bone Miner Res, 2007, 22(4):544-550. |
Fanciulli M, Norsworthy PJ, Petretto E, Dong R, Harper L, Kamesh L, Heward JM, Gough SC, De Smith A, Blakemore AI, Froguel P, Owen CJ, Pearce SH, Teixeira L, Guillevin L, Graham DS, Pusey CD, Cook HT, Vyse TJ, Aitman TJ.
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.
Nat Genet, 2007, 39(6):721-723. |
Ghoussaini M, Vatin V, Lecoeur C, Abkevich V, Younus A, Samson C, Wachter C, Heude B, Tauber M, Tounian P, Hercberg S, Weill J, Levy-Marchal C, Le Stunff C, Bougneres P, Froguel P, Meyre D.
Genetic Study of the Melanin-Concentrating Hormone Receptor 2 (MCHR2) in Childhood and Adulthood Severe Obesity.
J Clin Endocrinol Metab, 2007, Aug 14. |
Gueorguiev M, Wiltshire S, Garcia EA, Mein C, Lecoeur C, Kristen B, Allotey R, Hattersley AT, Walker M, O'rahilly S, Froguel P, Grossman AB, Mccarthy MI, Hitman GA, Korbonits M.
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a UK population with type 2 diabetes.
J Clin Endocrinol Metab, 2007, 92(6):2201-2204. |
Gutierrez-Aguilar R, Benmezroua Y, Vaillant E, Balkau B, Marre M, Charpentier G, Sladek R, Froguel P, Neve B.
Analysis of KLF transcription factor family gene variants in type 2 diabetes.
BMC Med Genet, 2007, 8(1):53. |
Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T.
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
Diabetologia, 2007, 50(4):747-751. |
Hummel M, Vasseur F, Mathieu C, Bellanne-Chantelot C, Froguel P, Standl E, Fuchtenbusch M.
Two Caucasian Families with the Hepatocyte Nuclear Factor-1Alpha Mutation Tyr218Cys.
Exp Clin Endocrinol Diabetes, 2007, 115(1):62-64. |
Meyre D, Bouatia-Naji N, Vatin V, Veslot J, Samson C, Tichet J, Marre M, Balkau B, Froguel P.
ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR
Study.
Diabetologia, 2007, 50(10):2090-2096. |
Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT, Zeggini E, Mccarthy MI.
Common Variation in the LMNA Gene (Encoding Lamin A/C) and Type 2 Diabetes : Association Analyses in
9,518 Subjects.
Diabetes, 2007, 56(3):879-883. |
Poulain-Godefroy O, Froguel P.
Preadipocyte response and impairment of differentiation in an inflammatory environment.
Biochem Biophys Res Commun, 2007, 356(3):662-667. |
Salonen JT, Uimari P, Aalto JM, Pirskanen M, Kaikkonen J, Todorova B, Hypponen J, Korhonen VP, Asikainen J, Devine C, Tuomainen TP, Luedemann J, Nauck M, Kerner W, Stephens RH, New JP, Ollier WE, Gibson JM, Payton A, Horan MA, Pendleton N, Mahoney W, Meyre D, Delplanque J, Froguel P, Luzzatto O, Yakir B, Darvasi A.
Type 2 diabetes whole-genome association study in four populations : the DiaGen consortium.
Am J Hum Genet, 2007, 81(2):338-345. |
Saunders CL, Chiodini BD, Sham P, Lewis CM, Abkevich V, Adeyemo AA, De Andrade M, Arya R, Berenson GS, Blangero J, Boehnke M, Borecki IB, Chagnon YC, Chen W, Comuzzie AG, Deng HW, Duggirala R, Feitosa MF, Froguel P, Hanson RL, Hebebrand J, Huezo-Dias P, Kissebah AH, Li W, Luke A, Martin LJ, Nash M, Ohman M, Palmer LJ, Peltonen L, Perola M, Price RA, Redline S, Srinivasan SR, Stern MP, Stone S, Stringham H, Turner S, Wijmenga C,A, Collier D.
Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity.
Obesity (Silver Spring), 2007, 15(9):2263-2275 |
Siddiq A, Gueorguiev M, Samson C,Hercberg S, Heude B, Levy-Marchal C, Jouret B, Weill J, Meyre D, Walley A, Froguel P.
Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects.
Diabetologia, 2007, 50(3):574-584. |
Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson Tj, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P.
A Genome-Wide Association Study Identifies Novel Risk Loci For Type 2 Diabetes.
Nature, 2007, 445(7130):881-885. |
Smith AJ, Tsalenko A, Sampas N, Scheffer A, Yamada NA, Tsang P, Ben-Dor A, Yakhini Z, Ellis RJ, Bruhn L, Laderman S, Froguel P, Blakemore AI.
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males :
implications for association studies of complex diseases.
Hum Mol Genet, 2007, 16(23):2784-2794. |
Stutzmann F, Vatin V, Cauchi S, Morandi A, Jouret B, Landt O, Tounian P, Levy-Marchal C, Buzzetti R, Pinelli L, Balkau B, Horber F, Bougneres P, Froguel P, Meyre D.
Non synonymous polymorphisms in Melanocortin-4 receptor protect against obesity : the two facets of a Janus obesity gene.
Hum Mol Genet, 2007, 16(15):1837-1844. |
Valayannopoulos V, Vaxillaire M, Aigrain Y, Jaubert F, Bellanne-Chantelot C,Ribeiro MJ, Brunelle F, Froguel P, Robert JJ, Polak M, Nihoul-Fekete C, De Lonlay P.
Coexistence in the same family of both focal and diffuse forms of hyperinsulinism.
Diabetes Care, 2007, 30(6):1590-1592. |
Vasseur F, Guerardel A, Barat-Houari M, Cottel D, Amouyel P, Froguel P, Helbecque N.
Impact of a CART promoter genetic variation on plasma lipid profile in a general population.
Mol Genet Metab, 2007, 90(2):199-204. |
Vaxillaire M, Dechaume A, Busiah K, Cave H, Pereira S, Scharfmann R, Perez De Nanclares G, Castano L,
Froguel P, Polak M.
New ABCC8 mutations in Relapsing Neonatal Diabetes and Clinical Features.
Diabetes, 2007, 56(6):1737-1741. |
Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T.
Targeted Disruption of AdipoR1 and AdipoR2 Causes Abrogation of Adiponectin Binding and Metabolic Actions.
Nat Med, 2007, 13(3):332-339. |
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Babenko AP, Polak M, Cave H, Busiah K, Czernichow P, Scharfmann R, Bryan J, Aguilar-Bryan L, Vaxillaire M, Froguel P.
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.
N Engl J Med, 2006, 355(5):456-466. |
Benzinou M, Walley A, Lobbens S, Charles MA, Jouret B, Fumeron F, Balkau B, Meyre D, Froguel P.
Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians.
Diabetes, 200, 55(10):2876-2882. |
Bouatia-Naji N, Meyre D, Lobbens S, Seron K, Fumeron F, Balkau B, Heude B, Jouret B, Scherer PE, Dina C, Weill J, Froguel P.
ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity.
Diabetes, 2006, 55(2):545-550. |
Cauchi S, Meyre D, Choquet H, Dina C, Born C, Marre M, Balkau B, Froguel P.
TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population : The Data From an Epidemiological Study on the insulin Resistance Syndrome (DESIR) Study.
Diabetes 2006, 55(11):3189-3192.
Erratum in : Diabetes. 2006, 55(12):3635. |
Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, Balkau B, Charpentier G, Pattou F, Stetsyuk V,
Scharfmann R, Staels B, Fruhbeck G, Froguel P.
Transcription factor TCF7L2 genetic study in the French population : expression in human beta-cells and
adipose tissue and strong association with type 2 diabetes.
Diabetes, 2006, 55(10):2903-2908. |
Cheyssac C, Lecoeur C, Dechaume A, Bibi A, Charpentier G, Balkau B, Marre M, Froguel P, Gibson F, Vaxillaire M.
Analysis of common PTPN1 gene variants in type 2 diabetes, obesity andassociated phenotypes in the French population.
BMC Med Genet, 2006, 5;7(1):44. |
Cheyssac C, Dina C, Lepretre F, Vasseur-Delannoy V, Dechaume A, Lobbens S, Balkau B, Ruiz J, Charpentier G, Pattou F, Joly E, Prentki M, Hansen T, Pedersen O, Vaxillaire M, Froguel P.
EIF4A2 Is a Positional Candidate Gene at the 3q27 Locus Linked to Type 2 Diabetes in French Families.
Diabetes, 2006,55(4):1171-1176. |
Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, Mccarthy MI, Zeggini E, Hasstedt SJ, Elbein SC.
Polymorphisms in the glucokinaseassociated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.
Diabetes, 2006, 55(9):2631-2639. |
Guerardel A, Tanko LB, Boutin P, Christiansen C, Froguel P.
Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women.
Osteoporos Int, 2006, 17(1):156-157. |
Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Tobe K, Nagai R, KadowakI T.
Hepatocyte Nuclear Factor-4{alpha} P2 promoter haplotypes are associated with Type 2 Diabetes in the
Japanese Population.
Diabetes, 2006, 55(5):1260-1264. |
Jaziri R, Lobbens S, Aubert R, Pean F, Lahmidi S, Vaxillaire M, Porchay I, Bellili N, Tichet J, Balkau B, Froguel P, Marre M, Fumeron F.
The PPARG Pro12Ala Polymorphism Is Associated With a Decreased Risk of Developing Hyperglycemia Over 6 Years and Combines With the Effect of the APM1 G-11391A Single Nucleotide Polymorphism : The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study.
Diabetes, 2006, 55(4):1157-1162. |
Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D,
Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, Blackwood A, Hung CC, Wareham NJ, Froguel P, Millhauser GL, O'rahilly S, Farooqi IS.
A POMC variant implicates betamelanocyte-stimulating hormone in the control of human energy balance.
Cell Metab, 2006, 3(2):135-140. |
Meyre D, Froguel P.
ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes.
Med Sci (Paris), 2006, 22(3):308-312. |
Santos JL, Boutin P, Verdich C, Holst C, Larsen LH, Toubro S, Dina C, Saris WH, Blaak EE, Hoffstedt J, Taylor MA, Polak J, Clement K, Langin D, Astrup A, Froguel P, Pedersen O, Sorensen TI, Martinez JA; The Nugenob* Consortium.
Genotype-by-nutrient interactions assessed in European obese women : a case-only study.
Eur J Nutr, 2006, 45(8):454-462. |
Seron K, Corset L, Vasseur F, Boutin P, Gomez-Ambrosi J, Salvador J, Fruhbeck G, Froguel P.
Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and
subcutaneous fat of lean and obese women.
Biochem Biophys Res Commun, 2006, 348(4):1232-1238. |
Sorensen TI, Boutin P, Taylor MA, Larsen LH, Verdich C, Petersen L, Holst C, Echwald SM, Dina C, Toubro S,
Petersen M, Polak J, Clement K, Martinez JA, Langin D, Oppert JM, Stich V, Macdonald I, Arner P, Saris WH, Pedersen O, Astrup A, Froguel P.
Genetic Polymorphisms and Weight Loss in Obesity : A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets.
PLoS Clin Trials, 2006, 1(2):e12. |
Tsuchiya T, Schwarz PE, Bosque-Plata LD, Geoffrey Hayes M, Dina C, Froguel P, Wayne Towers G, Fischer S, Temelkova-Kurktschiev T, Rietzsch H, Graessler J, Vcelak J, Palyzova D, Selisko T, Bendlova B, Schulze J, Julius U, Hanefeld M, Weedon MN, Evans JC, Frayling TM, Hattersley AT, Orho-Melander M, Groop L, Malecki MT, Hansen T, Pedersen O, Fingerlin TE, Boehnke M, Hanis CL, Cox NJ, Bell GI.
Association of the calpain-10 gene with type 2 diabetes in Europeans : Results of pooled and meta-analyses.
Mol Genet Metab, 2006, 89(1-2):174-184. |
Vasseur F, Meyre D, Froguel P.
Adiponectin, type 2 diabetes and the metabolic syndrome : lessons from human genetic studies.
Expert Rev Mol Med, 2006, 8(27):1-12. |
Vaxillaire M, Dechaume A, Vasseur-Delannoy V, Lahmidi S, Vatin V, Lepretre F, Boutin P, Hercberg S, Charpentier G, Dina C, Froguel P.
Genetic Analysis of ADIPOR1 and ADIPOR2 Candidate Polymorphisms for Type 2 Diabetes in the Caucasian
Population.
Diabetes, 2006, 55(3):856-861. |
Vaxillaire M, Froguel P.
Genetics basis of maturity-onset diabetes of the young.
Endocrinol Metab Clin North Am, 2006, 35(2):371-384. |
Vu-Hong TA, Durand E, Deghmoun S, Boutin P, Meyre D, Chevenne D, Czernichow P, Froguel P, Levy-Marchal C.
The INS VNTR locus does not associate with Smallness for Gestational Age (SGA), but interacts with SGA to increase insulin resistance in young adults.
J Clin Endocrinol Metab, 2006, 91(6):2437-2440. |
Walley AJ, Blakemore AI, Froguel P.
Genetics of obesity and the prediction of risk for health.
Hum Mol Genet, 2006, 15 Spec No 2:R124-130. |
Wiltshire S, Bell JT, Groves CJ Dina C, Hattersley AT, Frayling TM, Walker M, Hitman GA, Vaxillaire M, Farrall M, Froguel P, Mccarthy MI.
Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern
Europeans.
Ann Hum Genet, 2006, 70(Pt 6):726-737. |
Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, NG MC, O'Connell Jr, Pollin TI, Vaxillaire M, Walker M, Wang X, Whittaker P, Kunsun X, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, Mccarthy MI.
Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.
Diabetes, 2006, 55(9):2541-2548. |
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