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Publications 2007
Publications 2006
PhD 2006

 

LES PUBLICATIONS

UMR 8161 Institut de Biologie de Lille
Directeur : Yvan DE LAUNOIT
CNRS UMR 8161
Institut Pasteur de Lille
Université de Lille 1 - Université de Lille 2
Rattachée à l'IFR 142
Axe Cancer
Mots clés
Cancer. c-MET. Apoptosis senescence. NF-KB. Metastasis. PEA3. HIC1. Biostructure. Chimie des biomolécules. Angiogenesis. Ets. Parvovirus.
Contact : Yvan DE LAUNOIT
00 33 3 20 87 11 17

Publications 2007
Allan G, Barbet S, Coffinier Y, Delerue C, Deresmes D, Diarra M, Diesinger H, Grandidier B, Marcon L, Mélin T, Melnyk O, Stiévenard D, Wirtz L, Zdrojek M.
Fundamental studies in nanosciences at the institute of electronics, microelectronics, and nanotechnology (IEMN).
Int J Nanotechnol, 2007 in press.

Akazawa D, Date T, Morikawa K, Murayama A, Miyamoto M, Kaga M, Barth H, Baumert T, Dubuisson J, Wakita T.
CD81 expression is important for heterogeneous HCV permissiveness of Huh7 cell clones.
J Virol, 2007 81 :5036-5046.

Antoine AF, Montpellier C, Cailliau K, Browaeys-poly E, Vilain JP, Dubuisson J.
The Alphavirus 6K protein activates endogenous ionic conductances when expressed in Xenopus oocytes.
J Membr Biol, 2007, 215(1):37-48.

Aumercier M.
Stromelysin-1.
Encyclopedia of Cancer, 2nd Edition, Springer, Heidelberg, Editor Dr. Manfred Schwab, 2007, in press.

Baert JL, Beaudoin C, Monte D, Degerny C, Mauen S, de Launoit Y.
The 26S proteasome system degrades the ERM transcription factor and regulates its transcription enhancing activity.
Oncogene, 2007, 26(3):415-424.

Bensemain F, Hot D, Ferreira S, Dumont J, Bombois S, Maurage C-A, Huot L, Hermant X, Levillain E, Hubans C, Hansmannel F, Chapuis J, Hauw J-J, Schraen S,Lemoine Y, Buee L, Berr C, Mann D, Pasquier F, Amouyel P And Lambert J-C.
Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease.
Mol Psychiatry, 2007, Sept 250

Biet F, Angela de Melo Marques M, Grayon M, Xavier da Silveira EK, Brennan PJ, Drobecq H, Raze D, Vidal Pessolani MC, Locht C, Menozzi F.
Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence.
Microbes Infect, 2007, 9(2):175-82.

Bompard C, Herrou J, Antoine R, Leroy A, Rucktooa P, Hot D, Huvent I, Locht C, Villeret V, Jacob-Dubuisson F.
Structure–based mechanism of ligand binding for periplasmic solute-binding protein of the Bug Family.
J Mol Biol, 2007, 373(4):954-964.

Brochot E, Duverlie G, Castelain S, Morel V, Wychowski C, Dubuisson J, Francois C.
Effect of ribavirin on the hapatitis C virus (JFH-1) and its correlation with interferon sensitivity.
Antivir Ther, 2007, 12 (5):805-813.

Burgers WA, Blanchon L, Pradhan S, de Launoit Y, Kouzarides T, Fuks F.
Viral oncoproteins target the DNA methyltransferases.
Oncogene, 2007, 26(11):1650-1655.

Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L.
ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
Mol Endocrinol, 2007, 21(8):1835-1846.

Castelain S, Bonte D, Penin F, Francois C, Capron D, Dedeurwaerder S, Zawadzki P, Morel V, Wychowski C, Duverlie G.
Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine.
J Med Virol, 2007, 79:144-154.

Chapel C, Garcia C, Bartosh B, Roingeard P, Zitzmann N, Cosset FL, Dubuisson J, Dwek RA, Trépo C, Zoulim F, Durantel D.
Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors.
J Gen Virol, 2007, 8 :133-143.

Chevalier C, Saulnier A, Benureau Y, Flechet D, Delgrange D, Colbere-Garapin F, Wychowski C, Martin A.
Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs.
Mol Ther, 2007, 15:1452-1462.

Ciczora Y, Callens N, Penin F, Pécheur EI, Dubuisson J.
The transmembrane domains of HCV envelope glycoproteins: residues involved in E1E2 heterodimerization and involvement of these domains in virus entry.
J Virol, 2007, 81(5):2372-2381.

Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V.
Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily.
Science, 2007, 317:957-961.

Coffinier Y, Szunerits S, Jama C, Desmet R, Melnyk O, Marcus B, Gengembre L, Payen E, Delabouglise D, Boukherroub R.
Peptide immobilization on amine-terminated boron-doped diamond surfaces.
Langmuir, 2007, 23 :4494-4497.

Coffinier Y, Szunerits S, Marcus B, Desmet R, Melnyk O, Gengembre L, Payen E, Delabouglise D, Boukherroub R.
Covalent linking of peptides onto oxygen-terminated boron-doped diamond surfaces.
Diamond Relat mat, 2007, 16:892-898.

Delarue-Cochin S, Paunescu E, Maes L, Mouray E, Sergheraert C, Grellier P, Melnyk P.
Synthesis and Antimalarial Activity of New Analogues of Amodiaquine.
Eur J Med Chem, 2007, April 3.

Delgrange D, Pillez A, Castelain S, Cocquerel L, Rouillé Y, Dubuisson J, Wakita T, Duverlie G, Wychowski C.
Production of infectious hepatitis C virus with adaptive or specific mutations.
J Gen Virol, 2007, 88:2495-2503.

Dezitter X, Hammoudi F, Belverge N, Deloulme JC, Drobecq H, Masselot B, Formstecher P, Mendy D, Idziorek T.
Proteomics unveil corticoid-induced S100A11 shuttling in keratinocyte differentiation.
Biochem Biophys Res Commun, 2007, 360 (3):627-32.

Dubs P, Bourel-Bonnet L, Subra G, Blanpain A, Melnyk O, Pinel AM, Gras-Masse H, Martinez J.
Parallel synthesis of a lipopeptide library by hydrazone-based chemical ligation.
J Comb Chem, 2007, 9(6):973-981.

Dubuisson J.
Hepatitis C virus proteins.
World J Gastroenterol, 2007, 13(17):2406-2415.

Duverlie G, Wychowski C.
Cell culture systems for the hepatitis C virus.
World J Gastroenterol, 2007, 13:2442-2445.

El-Mahdi O, Souplet V, Carion O, Roux C, Garcia JM, Maillet C, Olivier C, Durand JO, Melnyk O.
Semicarbazide/a-oxo aldehyde site-specific ligation chemistry. From peptide microarrays to the micropatterning of polycarbonate or titanium oxide using silica nanoparticles.
Chapitre d’ouvrage, 2007, in press.

Fournier C, Duverlie G, Francois C, Schnuriger A, Dedeurwaerder S, Brochot E, Capron D, Wychowski C, Thibault V, Castelain S.
A focus reduction neutralization assay for hepatitis C virus neutralizing antibodies.
Virol J, 2007, 4:35

Foveau B, Leroy C, Ancot F, Deheuninck J, Ji Z, Fafeur V, Tulasne D.
Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor.
Cell Death Differ, 2007, 14(4):752-764.


Gatignol A, Dubuisson J, Wainberg MA, Cohen EA, Darlix JL.
New pandemics : HIV and AIDS, HCV and chronic hepatitis, influenza virus and flu.
Retrovirology, 2007, 1:4-8.

Helle F, Dubuisson J.
Hepatitis C Virus entry into host cells.
Cell Mol Life Sci, 2007, Oct 4.

Helle F, Goffard A, Morel V, Duverlie G, McKeating J, Keck ZY, Foung S, Penin F, Dubuisson
J, Voisset C.
The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein.
J Virol, 2007, 81(15):8101-8111.

Host H, Drobecq H, Locht C, Menozzi F.
Enzymatic methylation of the Mycobacterium tuberculosis heparin-binding haemagglutinin.
FEMS Microbiol Lett, 2007, 268(2):144-150.

Ji Z, Degerny C, Vintonenko N, Deheuninck J, Foveau B, Leroy C, Coll J, Tulasne D, Baert JL,
Fafeur V.
Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation.
Oncogene, 2007, 26(3):395-406.

Johansson DX, Voisset C, Tarr AW, Aung M, Ball JK, Dubuison J, Persson M.
Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus.
Proc Natl Acad Sci USA, 2007, 104(41):16269-16274.

Lavie M, Goffard A, Dubuisson J.
Assembly of a functional HCV glycoprotein heterodimer.
Curr Issues Mol Biol, 2007, 9:71-86.

Le Bras A, Lionneton F, Mattot V, Lelievre E, Caetano B, Spruyt N, Soncin F.
HIF-2alpha specifically activates the VE-cadherin promopter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites.
Oncogene, 2007, 26(53):7480-7489.

Leotoing L, Manin M, Monte D, Baron S, Communal Y, Lours C, Veyssiere G, Morel L, Beaudoin C.
Crosstalk between androgen receptor and epidermal growth factor receptor-signalling pathways: a molecular switch for epithelial cell differentiation.
J Mol Endocrinol, 2007, 39(2):151-162.

Marcon L, Stiévenard D, Melnyk O.
Electrical detection of antibodies from human serum based on the insertion of gold-labeled secondary antibodies into micro or nanogaps.
Chapitre d’ouvrage, 2007, in press.

Marcon L, Stiévenard D, Melnyk O.
Electrical detection of human immunoglobulins from human serum using a microbiosensor.
Biosens Bioelectr, 2007, 23(1):81-87.

Martien S, Abbadie C.
Acquisition of oxidative damage during senescence: the first step towards carcinogenesis.
Annals New York Acad Sci, 2007, in press.

Medina-Palazon C, Gruffat H, Mure F, Filhol O, Vingtdeux-Didier V, Drobecq H, Cochet C, Sergent N, Sergent A, Manet E.
Protein Kinase CK2 phosphorylation of EB2 regulates its function in the production of EBV infectious viral particles.
J Virol, 2007, 81(21):11850-11860.

Nguyen TL, Walque S, Veithen E, Dekoninck A, Martellini V, de Launoit Y, Burny A, harrod R, Van Lint C.
Transcriptional regulation of the bovine leukemia virus promoter by the cyclic AMP-response element modulator tau Isoform.
J Biol Chem, 2007, 282(29):20854-20867.

Pancre V, Delhem N, Yazdanpanah Y, Delanoye A, Delacre M, Depil S, Morales O, Mouton Y, Auriault C.
Presence of HIV-1 Nef specific CD4 T cell response is associated with non-progression in HIV-1 infection.
Vaccine, 2007, 25(31):5927-5937.

Paunescu E, Matuszak N, Grosu I, Melnyk P.
Suzuki coupling reaction as the key step for the synthesis of 4’-substituted analogues of Amodiaquine.
Tetrahedron, 2007, in press.

Pierrot C, Adam E, Hot D, Lafitte S, Capron M, George Jd, Khalife J.
Contribution of T cells and neutrophils in protection of young susceptible rats from fatal experimental malaria.
J Immunol, 2007, 178(3):1713-1722.

Roux C, Chai F, Ollivier N, Winter S, Melnyk O, Hildebrandt HF.
Ti-Cp functionalization by deposition of organic/inorganic silica nanoparticles.
Biomol Engin, 2007, in press.

Rucktooa P, Antoine R, Herrou J, Huvent I, Locht C, Jacob-Dubuisson F, Villeret V, Bompard C.
Crystal structures of two Bortdetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily.
J Mol Biol, 2007, 370:93-106.

Souplet V, Carion O, Maillet C, Olivier C, Médard N, Durand JO, Melnyk O.
Chemicals micropatterning of polycarbonate for site-specific peptide immobilization and biomolecular interactions??.
Chem Bio Chem, 2007, 8:315-322.

Souplet V, Desmet R, Melnyk O.
Imaging of protein layers with an optical microscope for the characterization of peptid microarrays.
J Pept Sci, 2007, 451-457.

Spencer HL, Eastham AM, Merry CL, Southgate TD, Perez-Campo F, Soncin F, Ritson S, Kemler R, stern PL Ward CM.
E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells.
Mol Biol Cell, 2007, 18(8):2838-2851.

Stankovic-Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guerardel C, Dejean A, Leprince D.
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.
Mol Cell Biol, 2007, 27(7):2661-2675

Vingtdeux V, Hamdane M, Loyens A, Gelé P, Drobecq H, Begard S, Galas MC, Delacourte A, Beauvillain JC, Buée L, Sergeant N.
Alkalizing drugs induce accumulation of Amyloid Precursor Protein byproducts in luminal vesicles of multivesicular bodies.
J Biol Chem, 2007, in press.

Wohlkonig A, Senechal M, Dewitte F, Backers K, Erneux C, Villeret V.
Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P(3)5 phosphatase.
Protein Expr Purif, 2007, 55 :69-74.

Yan Y, Tulasne D, Browaeys E, Cailliau K, Khayath N, Pierce RJ, Trolet J, Fafeur V, Younes AB, Dissous C.
Molecular cloning and characterisation of SmSLK, a novel Ste20-like kinase in Schistosoma mansoni.
Int J Parasitol, 2007.

Zdnanov S, Bernard D, Debacq-Chainiaux F, Martien S, Gosselin K, vercamer C, Chelli F, Toussaint O, Abbadie C.
Normal or stress-induced fibroblast senescence involves COX-2 activity.
Exp Cell Res, 2007, 313(14):3046-3056.

Zhang Q, Wang SY, Fleuriel C, Leprince D, Rocheleau JV, Piston DW, Goodman RH.
Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.
Proc Natl Acad sci USA, 2007, 104(3):829-833.
 
Publications 2006
Baillat D, Leprivier G, Regnier D, Vintonenko N, Begue A, Stehelin D,  Aumercier M,
Stromelysin-1 expression is activated in vivo by Ets-1 factor through palindromic head to head Ets binding sites present in the promoter.
Oncogene, 2006, 25:5764-5776.

Barras A, Dupont N, Horvath D, Melnyk P.
Design and Synthesis of new Met kinase inhibitors.
Fun Clin Pharmacol, 2006, 20:621

Belouzard S, Rouillé Y.
The ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis.
EMBO J, 2006, 25:932-942.

Bernard D, Gil J, Dumont P, Rizzo S,  Monté D, Quatannens B,  Hudson D,  Visakorpi T, Fuks F, De Launoit Y.
The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth.
Oncogene, 2006, 25:1358-1366.

Biot C, Daher W, Jarry C, Ndiaye EHCM, Pelinski L, Khalife J, Fraisse L, Brocard J., Melnyk P, Forfar Bares I, Dive D.
Probing the role of the covalent linkage of ferrocene into a chloroquine template.
J Med Chem, 2006, 49:4707-4714.

Blanchard E, Belouzard S, Goueslain L, Wakita T, Dubuisson J, Wychowski C, Rouillé Y.
Hepatitis C entry depends on clathrin-mediated endocytosis.
J Virol, 2006, 80:6994-6972.

Bockstaele L, Kooken L, Libert F, Paternot S, Dumont JE, De Launoit Y, Roger PP, Coulonval K.
Regulated activating Thr 172-phosphorylation of CDK4 : its relationship with cyclins and CDK “inhibitors”.
Mol Cell Biol, 2006, 26:5070-5785.

Breiman A, Vitour D, Delgrange D, Ottone C, Molina S, Pichard L, Fournier C, Charneau P, Duverlis G, Wychowski C, Maurel P, Meurs E.
An HCV NS3/4A protease-dependent strategy for the identification of hepatitis C virus-expressing cells.
J Gen Virol, 2006, 87:3587-3598.

Brinkmann M, Blossey R, Marcon L, Stiévenard D, Dufrêne YF, Melnyk O.
Fluidics of an nanogap.
Langmuir, 2006, 23:9784-9788.

Caetano B,  Drobecq H,  Soncin F.
Expression and purification of recombinant vascular endothelial-statin.
Protein Expr Purif, 2006, 46(1):136-142.

Caillet-Fauquet P, Di Giambattista,  De Launoit Y, Laub R.
Does quantification of virus transcription provide a real measure of parvovirus B19 infectivity 

Carion O,  Lefebvre J, Dubreucq G,  Dahri-Correia L,  Correia J,  Melnyk O.
Polysaccharide microarrays for polysaccharide-platelet-derived growth factor interaction studies.
Chembiochem, 2006, 7(5):817-826.

Carion O, Lefebvre J, Dubreucq G, Dahri-Correia L, Correia J, Melnyk O.
Polysaccharide microarrays for polysaccharide-platelet-derived growth factor interaction studies.
J Pep Science, 2006, 12:734-738.

Caro V, Hot D, Guigon G, Hubans C, Arrive M, Soubigou G, Renauld-Mongenie G, Antoine R, Locht C, Lemoine Y, Guiso N. 
Temporal analysis of French Bordetella pertussis isolates by comparative whole-genome hybridization.
Microbes Infect, 2006, 2228-35.

Chapel C, Garcia C, Roingeard P, Zitzman N, Dubuisson J, Dwek RA, Trépo C, Zoulim F, Durantel D.
Study of the antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like-particles.
J Gen Virol, 2006, 87:861-871.

Chopin V, Leprince D.
HIC1 : le nœud du problème en 17p13.3.
Médecine/Sciences, 2006, 22:54-61.

Chotteau-Lelièvre A, Dollé P, Gofflot F.
Expression analysis of murine genes using in situ hybridization with radioactive and nonradioactively labeled RNA probes.
Methods Mol Biol, 2006, 326:61-87.

Cocquerel L, Voissel C, Dubuisson J.
Hepatitis C virus entry : potential receptors clathrin-mediated endocytosis.
J Gen Virol, 2006, 87:1075-1085.

Delacour D, Cramm-Behrens CI, Drobecq H, LeBivic A, Naim HY, Jacof R.
Requirement for galectin-3 in apical protein sorting.
Curr Biol, 2006, 16(4):408-414.

De Launoit Y, Baert JL, Chotteau-Lelièvre A, Monté D, Coutte L, Mauen S, Firlej V, Degerny C, Verreman K.
The Ets Transcription Factors of the PEA3 Group : Transcriptional Regulators in Metastasis. 
Biochim Biophys Acta, 2006, 1766:79-87.

De Launoit Y, Baert JL, Chotteau-Lelièvre A, Monté D, Coutte L, Mauen S, Firlej V, Degerny C, Verreman K.
Les facteurs de transcription du groupe PEA3 : régulateurs transcriptionnels dans le processus de cancérisation.
Bull Cancer, 2006, 93(10):985-989.

Depil S, Angyalosi G, Morales O, Delacre M, Delhem N, Francois V, Georges B, Hammer J, Maillere B, Auriault C, Pancre V.
Peptide-binding assays and HLA II transgenic Abeta degrees mice are consistent and complementary tools for identifying HLA II-restricted peptides.
Vaccine, 2006, 24(13):2225-2229.

Deramecourt V, Bombois S, Maurage C, Ghestem A, Drobecq H, Vanmechelen E, Lebert F, Pasquier F, Delacourte A.
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.
J Neuropathol Exp Neurol, 2006, 65(3):278-288.

Doussineau T, Durand JO, El-Mahdi O, Maillet C, Melnyk O, Olivier C, Smaïhi M.
Semicarbazide functionalized silicate nanoparticles for peptide ligation.
Eur J Inorg Chem, 2006:2766-2772.

Dreux M, Pietschamann T, Granier C, Voisset C, Ricard-Blum S, Mangeot PE, Keck Z, Foung S, Vu-Dac N, Dubuisson J, Bartenschlager R, Lavillette D, Cosset FL.
HDL inhibits neutralization by HCV antibodies via ternary interactçàj with the scavnger receptor BI.
J Biol Chem, 2006, 281:18285-18295.

Foveau B, Leroy C, Ancot F, Deheuninck J, Ji Z, Fafeur V. Tulasne D.
Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor.
Cell Death Differ, 2006, Online Publication, Dec 22.

Frenois F, Baulard AR, Villeret V.
Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis.
Tuberculosis, 2006, 86(2):110-114.

Garcia JM, Far S, Diesis E, Melnyk O.
Determination of glyoxylyl-peptide concentration using oxime chemistry and RP-HPLC analysis.
J Pep Science, 2006, 12:734-738.

Goormachtigh G, Ouk TS, Mougel A, Tranchand-Bunel D, Masy E, Le Clorennec C, Feuillard J, Bornkamm GW, Auriault C, Manet C, Faffeur V, Adriaenssens E, Coll J.
Autoactivation of the Epstein-Barr virus oncogenic protein LMP1 during type II latency through opposite roles of the NF-kappaB and JNK signaling pathways.
J Virol, 2006, 80:7382-7393.

Helle F, Wychowski C, Vu-Dac N, Gustafson KR, Voisset C, Dubuisson J.
Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans.
J Biol Chem, 2006, 281:25177-25183.

Hodak H, Clantin B, Willery E, Villeret V, Locht C, Jacob-Dubuisson F.
Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate.
Mol Microbiol, 2006, 61:368-382.

Huvent I, Belrhali H, Antoine R, Lecher S, Jacob-Dubuisson F, Villeret V, Bompard C.
Structural analysis of Bordetella pertussis BugE solute receptor in a bound conformation.
Acta Crystallogr D Biol Crystallogr, 2006, 62:1375-1381.

Jaillard S, Holder-Espinasse M, Hubert T, Copin MC, Duterque-Coquillaud M, Wurtz A, Marquette CH.
Tracheal replacement by allogenic aorta in the pig.
Chest, 2006, 130:1397-1404.

Ji Z, Degerny C, Vintonenko N, Deheuninck J,Foveau B, Leroy C, Coll J, Tulasne D,Baert JL, Fafeur V.
Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation.
Oncogene, 2006, Online Publication, July 24.

Kherrouche Z,  Blais A,  Ferreira E,  De Launoit Y, Monté D.
The apoptosis signal regulating kinase 1 is a direct E2F target gene.
Biochem J, 2006, 396:547-556.

Klingenstein R, Melnyk P, Leliveld RS, Ryckebusch A, Korth C.
Similar Structure Activity Relationships of Quinoline Derivatives for antiprion and antimalarial effects.
J Med Chem, 2006, 49:5300-5308.

Lavie M, Goffard A, Dubuisson J.
Assembly of a functional HCV glycoprotein heterodimer.
In : Hepatitis C viruses : Genomes and Molecular Biology, edited by S-L Tan,
Horizon Scientific Press, pp 121-150.

Lavie M, Voisset C, Vu-Dac N, Zurawski V, Duverlie G, Wychowski C, Dubuisson J.
Serum amyloid A has antiviral activity against hepatitis C virus by inhibiting virus entry in a cell culture system.
Hepatology, 2006, 44:1626-1634.

Le Clorennec C, Youlyouz-Marfak I, Adriaenssens E, Coll J, Bornkamm GW, Feuillard J.
EBV latency III immortalization program sensitizes B celles to induction of CD95-mediated apoptosis via LMP1 : role of NF-kappaB, STAT1, and p53.
Blood, 2006, 107:2070-2078.

Leroy C, Deheuninck J, Reveneau S, Foveau B, Ji Z, Villenet C, Quief S, Tulasne D, Kerckaert JP, Fafeur V.
HGF/SF regulates expression of apoptotic genes in MCF-10A.
Ann NY Acad Sci, 2006, 1090: 188-202.

Mauen S, Huvent I, Raussens V, Demonte D, Baert JL, Tricot C, Ruysschaert JM, Van Lint C, Moguilevsky N, De Launoit Y.
Expression, Purification, and Structural Prediction of the Ets Transcription Factor ERM.
Biochim Biophys Acta, 2006, 1760:1192-1201.

Melnyk P, Leroux V, Grellier P, Sergheraert C.
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library.
C Bioorg Med Chem Lett, 2006, 16:31-35.

Mijatovic T, Op de Beeck A,  Van Quaquebeke E, Dewelle J,  Darro F,  De Launoit Y, Kiss R.
The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells.
Mol Cancer Ther, 2006, 5:391-399.

Olivier O, Perzyna A, Coffinier Y, Grandidier B, Stievenard D, Melnyk O, Durand JO. 
Detecting the chemoselective ligation of peptides to silicon with the use of cobalt-carbonyl labels.
Langmui, 2006,22(16):7059-7075.

Paunescu E, Susplugas S, Mouray E, Grellier P, Melnyk P.
Design, Synthesis and Antimalarial activity of some new Amodiaquine and Amopyroquine analogues.
Fund Clin Pharmacol, 2006, 20:625.

Rouillé Y, Helle F, Delgrange R, Roingeard P, Voisset C, Blanchard E, Belouzard S, McKeating J, Platel AH, Maertens G, Wakita T, Wychowski D, Dubuisson J.
Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus.
J Virol, 2006, 80:2832-2841.

Rucktooa P, Huvent I, Antoine R, Lecher R, Jacob-Dubuisson F, Villeret V, Bompard C.
Crystallization and preliminary x-ray diffraction analysis of two extracytoplasmaic solute receptor for the DctP family from Bordetella pertussis.
Acta Crystallogr Sect F Struct Biol Cryst Comun, 2006, 62:970-972.

Safi R, Vlaeminck-Guillem V, Duffraisse M, Seugnet I, Plateroti M, Martgotat A, Duterque-Coquillaud M,
Crespi J, Denver R, Demeinex B, Laudet V.
Paedomorphosis revisited : Thyroid hormone receptors are functional in Necturus maculosus.
Evol Dev, 2006, 8:284-292.

Servais C, Caillet-Fauquet P, Draps ML, Velu, T, De Launoit Y, Brandenburger A.
Hypoxic-response elements in the oncolytic parvovirus Minute virus of mice do not allow for increased vector production at low oxygen concentration.
J Gen Virol, 2006, 87:1197-1201.

Stankovic-Valentin N, Verger A, Deltour S, Quinland KRG, Guerardel C, Crossley M, Leprince D.
A L225A substitution in the human tumor suppressor gene HIC1 abolishes its interaction with the corepressor CtBP.
FEBS J, 2006, 273:2879-2980.

Toussaint M, Cazenave Gassiot A, Charton J, Melnyk P.
Synthesis and Evaluation of Tetrahydroquinoline-Hydantoine Derivatives as s1 Receoptor Selective Ligands.
Fund Clin Pharmacol, 2006, 20:626.

Trottier J, Verreault M, Grepper S, Monté D, Bélanger J, Kaeding J, Caron P, Inaba TT, Barbier O.
Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.
Hepatology, 2006, 44(5):1158-1170.

Vandeput F, Backers K, Villeret V, Pasesse X, Erneux C.
The influence of anionic lipds on SHIP2 phosphotidylinositol3,4,5-triphosphate 5-phosphatase activity.
Cell Signal, 2006, 18:2193-2199.

Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F.
The Polycomb group protein EZH2 directly controls DNA methylation.
Nature, 2006  439:871-874.


Vlaeminck-Guillem V, Safi R, Guillem P, Leteurtre E, Duterque-Coquillaud M, Laudet V. 
Thyroid hormone expression in the obligatory paedomorphic salamander Necturus maculosus.
Int J Dev Biol, 2006, 50:553-560.

Voisset C, Op de Beeck A, Horellou P, Dreux M, Gustot T, Duverlie G, Cosset FL, Vu-Dac N, Dubuisson J.
High-density lipoproteins reduce the neutralizing effect of hepatitis C virus (HCV)-infected patient antibodies by promoting HCV entry.
J Gen virol, 2006, 87:2577-2581.
 
PhD 2006
Bertrand CAETANO
Directeur de thèse : Fabrice Soncin
«Etude du rôle de l’expression de la VE-statine (egfl7), un facteur spécifiquement exprimé par les cellules endothéliales des vaisseaux sanguins»
Université de Lille 2
Le 21/11/2006
Yann CICZORA
Directeur de thèse : Jean Dubuisson
«Rôles fonctionnels des domaines transmembranaires des glycoprotéines d’enveloppe E1 et E2 du virus de l’hépatite C»
Université de Lille 2
Le 14/11/2006
Julien DEHEUNINCK
Directeur de thèse : Véronique Fafeur
«Le récepteur MET une cible fonctionnelle des caspases»
Université de Lille 1
Le 03/11/2006
Muriel ESPINASSE (HOLDER)
Directeur de thèse : Martine Duterque
«Vers la compréhension de la formation et du vieillissement du cartilage à partir de deux modèles : souris transgéniques et remplacement trachéal»
Université de Lille 2
Le 15/11/2006
Virginie FIRJEF
Directeur de thèse : Anne Choteau
«Facteurs de transcription du groupe PEA3 et cancérogenèse mammaire : modèles d’inhibition de l’expression, études phénotypiques et recherche de gènes cibles»
Université de Lille 1
Le 24/11/2006
Frédéric FRENOIS
Directeur de thèse : Vincent Villeret
«Etudes structurales du facteur de transcription EthR de Mycobacteriumtuberculosis impliqué dans la résistance à l’antiberculeux éthionamide. Progrès dans l’analyse structurale des interactions entre le récepteur nucléaire LXRb humain et des ligands candidats médicaments»
Université de Lille 2
Le 01/02/2006
Gauthier GOORMACHTIGH
Directeur de thèse : Jean Coll
«Etude de LMP1, oncogène majeur du virus d’Estein-Barr : autoregulation de son expression par les effets antagonistes des voies de signalisation cellulaire JNK et NFkB»
Université de Lille 2
Le 20/06/2006
Christine HUBANS
Co-Direction de thèse : Yves Lemoine et Engelbert Mephu-Nguifo
«Méthode de prédiction ab initio l’opérons et validations biologiques chez les Bordetelles»
Université de Lille 1
Le 27/10/2006
Gabriel LEPRIVIER
Directeur de thèse : Marc Aumercier
«Les isoformes humaines de Ets-1 : rôle dans la régulation du promoteur de la Stromélysine»
Université de Lille 2
Le 10/11/2006
Nicolas STANKOVIC
Directeur de thèse : Dominique Leprince
«Etude du recrutement du CtBP et de la SUMOylation de la région centrale du produit du gène suppresseur de tumeurs H1C1»
Université de Lille 2
Le 27/10/2006
 
HDR
Ngoc VU-DAC
Directeur de thèse : Jean Dubuisson
Titre de la thèse : "Rôle des lipoprotéines, transfert lipidique et mécanismes d'entrée du virus de l'hépatite C (VHC) dans les hépatocytes".
Université de Lille 1
Le 22/12/2006

 


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