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Directeur :
INSERM U547
Institut Pasteur
de Lille
éde Lille 2
Rattachée à l'IFR 142
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| Parasitologie Immunologie et Inflammation |
Bilharzioses. Paludisme. Inflammation. Immunologie. Parasitologie. |
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Bahia D, Mortara RA, Kusel JR, Andrade LF, Ludolf F, Kuser PR, Avelar L, Trolet J, Dissous C, Pierce R.J, Oliveira G.
Schistosoma mansoni : Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration.
Exp Parasitol, 2007, 116: 225-232. |
Biot C, Daher W, Chavain N, Fandeur T, Khalife J, Dive D, De Clercq E.
Antimalarial hydroxyl ferroquine derivatives are active against human SARS-Coronavirus in vitro.
J Med Chem, 2007, In press. |
Bracher M, Gould HJ, Sutton BJ, Dombrowicz D, Karagiannis SN.
Three-colour flow cytometric method to measure antibody-dependent tumour cell killing by cytotoxicity and phagocytosis.
J Immunol Methods, 2007, 323:160-171. |
Breuilh L, Vanhoutte F, Fontaine J, van Stijn CM, Tillie-Leblond I, Capron M, Faveeuw C, Jouault T, van Die I, Gosset P, Trottein F.
Galectin 3 modulates immune and inflammatory responses during helminthic infection: impact of galectin 3 deficiency on the functions of dendritic cells.
Infect Immun, 2007, 75(11):5148-5157. |
Duboucher C, Barbier C, Beltramini A, Rona M, Ricome J, Morel G, Capron M, Pierce R, Dei-Cas E, Viscogliosi E.
Pulmonary superinfection by trichomonads in the course of acute respiratory distress syndrom.
Lung, 2007, 185(5):295-301. |
Duboucher C, Boggia R, Morel G, Capron M, Pierce R, Dei-Cas E, Viscogliosi E.
Pneumocystis pneumonia : immunodepression, Pneumocystis jirovecii … and the third man.
Nature Reviews Microbiology, 2007, In press. |
Dufernez F, Walker RL, Noel C, Caby S, Mantini C, Delgado-Viscogliosi P, Ohkuma M, Kudo T, Capron M, Pierce RJ, Villanueva MR, Viscogliosi E.
Morphological and Molecular Identification of Non-Tritrichomonas foetus Trichomonad Protozoa from the Bovine Preputial Cavity.
J Eukaryot Microbiol, 2007, 54:161-168. |
Guillou F, Mitta G, Galinier R, Coustau C.
Identification and expression of gene transcripts generated during an anti-parasitic response in Biomphalaria glabrata.
Dev Comp Immunol, 2007, 31:657-671. |
Hammad H, Kool M, Soullie T, Narumiya S, Trottein F, Hoogsteden HC, Lambrecht BN.
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells.
J Exp Med, 2007, 204:357-367. |
Honda K, Paumelle R, Ayral A, Faveeuw C, Nutten S, Woerly G, Fleury S, Papin JP, Staels B, Capron M, Dombrowicz D.
Peroxisome proliferator-activated receptor-a regulate anaphylaxis by acting on vasculature but not on mast cells.
J Exp Med, 2007, En revision. |
Karagiannis S, Bracher M, Beavil R, Beavil J, Hunt J, McCloskey N, McCloskey R, East N, Burke F, Sutton BJ, Dombrowicz D, Balkwill F, Gould H.
Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells.
Cancer Immunology Immunotherapy, 2007, 57(2):247-263. |
Khayath N, Vicogne J, Ahier A, Benyounes A, Konrad C, Trolet J, Viscogliosi E, Brehm K, Dissous C.
Diversification of the insulin receptor family in the helminth parasite Schistosoma mansoni.
Febs J, 2007, 274:659-676. |
Lefevre E, Bardot C, Noel C, Carrias JF, Viscogliosi E, Amblard C, Sime-Ngando T.
Unveiling fungal zooflagellates as members of freshwater picoeukaryotes: evidence from a molecular diversity study in a deep meromictic lake.
Environ Microbiol, 2007, 9:61-71. |
Legrand F, Woerly G, Driss V, Capron M.
Innate immune functions of eosinophils: from anti-parasite to anti-tumor cells.
Methods in Molecular Biology, 2007, In press. |
Legrand F, Driss V, Woerly G, Loiseau S, Hermann E, Fournie J, Dombrowicz D, Capron M.
Human eosinophils express a TCR/CD3 complex mediating reactivity towards mycobacteria and tumors.
Nature, 2007, en revision. |
Ludolf F, Bahia D, Cousin A, Capron M, Pierce R, Dissous C, Oliveira G.
Molecular analysis of SmFes, a novel tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family.
Gene, 2007, en revision. |
Mallevaey T, Fontaine J, Breuilh L, Paget C, Castro-Keller A, Vendeville C, Capron M, Leite-de-Moraes M, Trottein F, Faveeuw C.
Invariant and noninvariant natural killer T cells exert opposite regulatory functions on the immune response during murine schistosomiasis.
Infect Immun, 2007, 75:2171-2180. |
Michel ML, Keller AC, Paget C, Fujio M, Trottein F, Savage PB, Wong CH, Schneider E, Dy M, Leite-de-Moraes MC.
Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia.
J Exp Med, 2007, 204:995-1001. |
Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, Willems F, Goldman M, Goriely S.
IL-27 Synthesis Induced by TLR Ligation Critically Depends on IFN Regulatory Factor 3.
J Immunol, 2007, 178:7607-7615. |
Noel C, Noda S, Mantini C, Dolan MF, Moriya S, Delgado-Viscogliosi P, Kudo T, Capron M, Pierce RJ, Ohkuma M, Viscogliosi E.
Molecular Phylogenetic Position of the Genera Stephanonympha and Caduceia (Parabasalia) Inferred from Nuclear Small Subunit rRNA Gene Sequences.
J Eukaryot Microbiol, 2007, 54:93-99. |
Paget C, Mallevaey T, Speak AO, Torres D, Fontaine F, Sheehan K, Capron M, Ryffel B, Faveeuw C, Leite de Moraes M, Platt F, Trolet J.
Activation of iNKT cells by TLR9-stimulated myeloid dendritic cells requires type I interferon and charged glycosphingolipid(s).
Immunity, 2007, 27(4):597-609. |
Pierrot C, Adam E, Hot D, Lafite S, Capron G, George J, Khalife J.
Contribution of T cells and neutrophils in protection of young susceptible rats from fatal experimental malaria.
J Immunol, 2007, 178:1713-1722. |
Speak AO, Salio M, Neville DC, Fontaine J, Priestman DA. Platt N, Heare T, Butters TD, Dwek RA, Trottein F, Exley MA, Cerundolo V, Platt FM.
Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.
Proc Natl Acad Sci U S A, 2007, 104:5971-5976. |
Stensvold CR, Suresh GK, Tan KS, Thompson RC, Traub RJ, Viscogliosi E, Yoshikawa H, Clark CG.
Terminology for Blastocystis subtypes--a consensus.
Trends Parasitol, 2007, 23:93-96. |
Torres D, Paget C, Fontaine J, Maruyama M, Capron M, Gosset P, Faveeuw C, Trottein F.
Prostaglandin D2 inhibits the production of IFN- by invariant Natural Killer T cells: consequences in the control of B16 melanoma.
J Immunol, 2007, En revision. |
Vanhoutte F, Breuilh L, Fontaine J, Mallevaey T, Vendeville C, Vasseur V, Capron M, Goriely S, Faveeuw F, Ryffel B, Trottein F.
Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology.
Microbes Infect, 2007, Sept 26. |
Vanhoutte F, Breuilh L, Paget C, Fontaine J, vendeville C, Goriely S. Ryffel B, Trottein F.
Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells.
Immunol Letters, 2007, En revision. |
Wesley JD, Tessmer MS, Paget C, Trottein F, Brossay L.
A y chromosome-linked factor impairs NK T development.
J Immunol, 2007, 179:3480-3487. |
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Bahia D, Avelar L, Mortara RA, Khayath N, Yan Y, Noel C, Capron M, Dissous C, Pierce RJ, Oliveira G.
SmPKC1, a new protein kinase C identified in the platyhelminth parasite Schistosoma mansoni.
Biochem Biophys Res Commun, 2006, 345:1138-1148. |
Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Herve M, Miele AE, Trottein F, Brunori M, Bellelli A.
Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography.
J Mol Biol, 2006, 360:678-689. |
Bertin B, Oger F, Cornette J, Caby S, Noel C, Capron M, Fantappie MR, Rumjanek FD, Pierce RJ.
Schistosoma mansoni CBP/p300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1.
Mol Biochem Parasitol, 2006, 146:180-191. |
Biot C, Daher W, Chavain N, Fandeur T, Khalife J, Dive D, De Clercq E.
Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.
J Med Chem, 2006, 49:2845-2849. |
Biot C, Daher W, Ndiaye CM, Melnyk P, Pradines B, Chavain N, Pellet A, Fraisse L, Pelinski L, Jarry C, Brocard J, Khalife J, Forfar-Bares I, Dive D.
Probing the role of the covalent linkage of ferrocene into a chloroquine template.
J Med Chem, 2006, 49:4707-4714. |
Bonnard P, Remoue F, Schacht AM, Pialoux G, Riveau G.
Association between Serum Cytokine Profiles and Schistosomiasis-Related Hepatic Fibrosis: Infection by Schistosoma japonicum versus S. Mansoni.
J Infect Dis, 2006, 193:748-749. |
Bouchut A, Roger E, Coustau C, Gourbal B, Mitta G.
Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: Potential involvement of adhesion genes.
Int J Parasitol, 2006, 36:175-184. |
Bouchut A, Sautiere PE, Coustau C, Mitta G.
Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: Potential involvement of proteins from hemocytes revealed by a proteomic approach.
Acta Trop, 2006, 98:234-246. |
Daher W, Cailliau K, Takeda K, Pierrot C, Khayath N, Dissous C, Capron M, Yanagida M, Browaeys E, Khalife J.
Characterization of Schistosoma mansoni Sds homolog, a Leucine Rich Repeat protein, that interacts with protein phosphatase type 1 and interrupts a G2/M cell-cycle checkpoint.
Biochem J, 2006, 395:433-441. |
Daher W, Biot C, Fandeur T, Jouin H, Pelinski L, Viscogliosi E, Fraisse L, Pradines B, Brocard J, Khalife J, Dive D.
Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in the W2 strain under drug pressure.
Malar J, 2006, 5:11. |
Daher WE., Pelinski L, Klieber S, Sadoun F, Meunier V, Bourrie M, Biot C, Guillou F, Fabre G, Brocard J, Fraisse L, Maffrand JP, Khalife J, Dive D.
In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum.
Drug Metab Dispos, 2006, 34:667-682. |
Daher W, Browaeys E, Pierrot C, Jouin H, Dive D, Meurice E, Dissous C, Capron M, Tomavo S, Doerig C, Cailliau K, Khalife J.
Regulation of protein phosphatase type 1 and cell cycle progression by PfLRR1, a novel leucine-rich repeat protein of the human malaria parasite Plasmodium falciparum.
Mol Microbiol, 2006, 60:578-590. |
Dei-Cas E, Chabe M, Moukhlis R, Durand-Joly I, Aliouat el M, Stringer JR, Cushion M, Noel C, Sybren de Hoog G, Guillot J, Viscogliosi E.
Pneumocystis oryctolagi sp. nov., an uncultured fungus causing pneumonia in rabbits at weaning: review of current knowledge, and description of a new taxon on genotypic, phylogenetic and phenotypic bases.
FEMS Microbiol Rev, 2006, 30:853-871. |
Delcroix M, Sajid M, Caffrey CR, Lim K, Dvorak J, Hsieh I, Bahgat M, Dissous C, McKerrow JH.
A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.
J Biol Chem, 2006, 281:39316-39329. |
Dissous C, Khayath N, Vicogne J, Capron M.
Growth factor receptors in helminth parasites: signalling and host-parasite relationships.
FEBS Lett, 2006, 580:2968-2975. |
Duboucher C, Caby S, Dufernez F, Chabe M, Gantois N, Delgado-Viscogliosi P, Billy C, Barre E, Torabi E, Capron M, Pierce RJ, Dei-Cas E, Viscogliosi E.
Molecular identification of Tritrichomonas foetus-like organisms as coinfecting agents of human Pneumocystis pneumonia.
J Clin Microbiol, 2006, 44:1165-1168. |
Duboucher C, Caby S, Pierce R, Capron M, Dei-Cas E, Viscogliosi E.
Trichomonads as coinfecting agents in Pneumocystis pneumonia and acute respiratory distress syndrome.
J Eukaryot Microbiol, 2006, I53:595-597. |
Dufernez F, Yernaux C, Gerbod D, Noel C, Chauvenet M, Wintjens R, Edgcomb VP, Capron M, Opperdoes FR, Viscogliosi E.
The presence of four iron-containing superoxide dismutase isozymes in Trypanosomatidae: Characterization , subcellular localization, and phylogenetic origin in Trypanosoma brucei.
Free Radic Biol Med, 2006, 40:210-225. |
Frealle E, Noel C, Nolard N, Symoens F, Felipe M.S, Dei-Cas E, Camus D, Viscogliosi E, Delhaes L.
Manganese superoxide dismutase based phylogeny of pathogenic fungi.
Mol Phylogenet Evol, 2006, 41:28-39. |
Guillou F, Mitta G, Galinier R, Coustau C.
Identification and expression of gene transcripts generated during an anti-parasitic response in Biomphalaria glabrata.
Dev Comp Immunol, 2006. |
Hermann E, Alonso-Vega C, Berthe A, Truyens C, Flores A, Cordova M, Moretta L, Torrico F, Braud V, Carlier Y.
Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells.
Pediatr Res, 2006, 60:38-43. |
Jouault T, El Abed-El Behi M, Martinez-Esparza M, Breuilh L, Trinel PA, Chamaillard M, Trottein F, Poulain D.
Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling.
J Immunol, 2006, 177:4679-4687. |
Khayath N, Mithieux G, Zitoun C, Coustau C, Vicogne J, Tielens AG, Dissous C.
Glyceroneogenesis: an unexpected metabolic pathway for glutamine in Schistosoma mansoni sporocysts.
Mol Biochem Parasitol, 2006, 147:145-153. |
Mallevaey T, Zanetta JP, Faveeuw C, Fontaine J, Maes E, Platt F, Capron M, de-Moraes ML, Trottein F.
Activation of Invariant NKT Cells by the Helminth Parasite Schistosoma mansoni.
J Immunol, 2006, 176: 2476-2485. |
Oger F, Bertin B, Caby S, Dalia-Cornette J, Adams M, Vicogne J, Capron M, Pierce RJ.
Molecular cloning and characterization of Schistosoma mansoni Ftz-F1 interacting protein-1 (SmFIP-1), a novel corepressor of the nuclear receptor SmFtz-F1.
Mol Biochem Parasitol, 2006, 148:10-23. |
Paumelle R, Blanquart C, Briand O, Barbier O, Duhem C, Woerly G, Percevault F, Fruchart J C, Dombrowicz D, Glineur C, Staels B.
Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway.
Circ Res, 2006, 98:361-369. |
Pierrot C, Wilson S, Lallet H, Lafitte S, Jones FM, Daher W, Capron M, Dunne DW, Khalife J.
Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malaria.
Infect Immun, 2006, 74:3347-3354. |
Trottein F, Mallevaey T, Faveeuw C, Capron M, Leite-de-Moraes M.
Role of the natural killer T lymphocytes in Th2 responses during allergic asthma and helminth parasitic diseases.
Chem Immunol Allergy, 2006, 90:113-127. |
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Wassim DAHER
Directeur de thèse : Daniel Dive
« Nouvelles voies de lutte contre Plasmodium falciparum I. analogues ferrocéniques II. LRR : une nouvelle famille de protéines parasitaires ».
Thèse de Doctorat présentée à l’Université de Lille 2 pour l’obtention du titre de Docteur en Sciences de la Vie et de Santé, discipline Parasitologie/Biologie Moléculaire, Université Lille 2, 2006. |
Mélaine DELCROIX
Directeur de thèse : Colette Dissous et James McKerrow
« Digestion des protéines de l’hôte par le réseau de protéases intestinales du parasite Helminthe Scistosoma mansoni ».
Thèse (co-tutelle) de Doctorat présentée à l’Université de Lille 2 pour l’otention du titre de Docteur en Sciences de la Vie et de Santé, discipline Parasitologie/Biologie Moléculaire, Université Lille 2, 2006. |
Naji KHAYATH
Directeur de thèse : Colette Dissous
« Etude de l’adaptation de Schistosoma mansoni à son environnement nutritif : rôles dela glutaine dans le métabolisme énergétique du sporocyste et analyse de la diversification de la famille des récpeteurs de l’insuline chez le parasite ».
Thèse de Doctorat présentée à l’Université de Lille 2 pour l’obtention du titre de Docteur en Sciences de la Vie et de Santé, discipline Parasitologie/Biologie Moléculaire, Université Lille 2, 2006. |
Thierry MALLEWAEY
Directeur de thèse : François Trottein
« Etude du rôle des lymphocytes T Natural Killer au cours de la schistosomiase expérimentale murine ».
Thèse de Doctorat présentée à l’Université de Lille 2 pour l’obtention du titre de Docteur en Sciences de la Vie et de Santé, discipline Parasitologie/Biologie Moléculaire, Université Lille 2, 2006. |
Frédérik OGER
Directeur de thèse : Raymond Pierce
« Identification et caractérisation moléculaire et fonctionnelle de cofacteurs transcriptionnels spécifiques et conservés chez le parasite plathelminthe Schistosomia mansoni : rôle dans la régulation de l‘activité trancriptionnelle du récepteur SmFtz-F1 et dans le contrôle épigénétique de la transcription ».
Thèse de Doctorat présentée à l’Université de Lille 2 pour l’obtention du titre de Docteur en Sciences de la Vie et de Santé, discipline Parasitologie/Biologie Moléculaire, Université Lille 2, 2006. |
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Christelle FAVEEUW
Tuteur : François Trottein
« Etude du mode d’activation des lymphocytes T natural Killer : apport du modèle de la schistosomiase expérimentale murine ».
HDR : Habilitation à Diriger des Recherches, Université des Sciences et Technologies de Lille, 2006 |
Christine PIERROT
Tuteur : Jamal Khalife
« De la schistosomiase au paludisme âge – dépendant : apport du modèle rat ».
HDR : Habilitation à Diriger des Recherches, Université des Sciences et Technologies de Lille, 2006
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