2010
Adamczyk S, Robin E, Simerabet M, Kipnis E, Tavernier B, Vallet B, Bordet R, Lebuffe G.
Sevoflurane pre- and post-conditioning protect the brain via the mitochondrial K ATP channel.
Br J Anaesth, 2010, 104:191-200.

Beauvillain C, Meloni F, Sirard JC, Blanchard S, Jarry U, Scotet M, Magistrelli G, Delneste Y, Barnaba V, Jeannin P.
The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells.
J Hepatol, 2010, 52:644-51.

DeKruyff RH, Bu X, Ballesteros A, Santiago C, Chim YL, Lee HH, Karisola P, Pichavant M, Kaplan GG, Umetsu DT, Freeman GJ, Casasnovas JM.
T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.
J Immunol. 2010, 184:1918-30.

Marichal T, Bedoret D, Mesnil C, Pichavant M, Goriely S, Trottein F, Cataldo D, Goldman M, Lekeux P, Bureau F, Desmet CJ.
Interferon response factor 3 is essential for house dust mite-induced airway allergy.
J Allergy Clin Immunol, 2010, Jul 29.

Muñoz N, Van Maele L, Marqués JM, Rial A, Sirard JC, Chabalgoity JA.
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.
Infect Immun, 2010,

Renneson J, Guabiraba R, Pereira-Silkva RE, Ivanov S, Fontaine J, Paget C, Ryffel B, Quesniaux V, Faveeuw C, Teixeira M, Trottein F.
A detrimental role for invariant Natural Killer T cells in the pathogenesis of dengue virus infection.  
J Immunol, 2010, in press.

Torres D, Dieudonné A, Ryffel B, Vilain E, Si-Tahar M, Pichavant M, Lassalle P, Trottein F, Gosset P.
Double-Stranded RNA Exacerbates Pulmonary Allergic Reaction through TLR3: Implication of Airway Epithelium and Dendritic Cells.
J Immunol, 2010, 185:451-459.

Van Maele L, Carnoy C, Cayet D, Songhet P, Dumoutier L, Ferrero I, Janot L, Erard F, Bertout J, Leger H, Sebbane F, Benecke A, Renauld JC, Hardt WD, Ryffel B, Sirard JC.
TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa.
J Immunol, 2010, 185:1177-1185.

 

 

2009
Betbeder D, Trottein F.
The effect of alpha-galactosylceramide on the activation of Natural Killer T lymphocytes.
Vaccine, 2009, 27:3691.

Bialecki E, Paget C, Fontaine J, Capron M, Trottein F, and Faveeuw C.
Role of marginal zone B lymphocytes in invariant Natural Killer T cell activation.
J Immunology, 2009, 82: 6105-6113.

Boutoille D, Marechal X, Pichenot M, Chemani C, Guery B, Faure K.
FITC-albumin as a marker for assessment of endothelial permeability in mice: comparison with 125I-albumin.
Exp Lung Res, 2009, 35:263-271.

Carnoy C, Roten CA.
The dif/Xer recombination systems in proteobacteria.
PLoS One, 2009, 4:e6531.

Chemani C, Imberty A, de Bentzmann S, Pierre M, Wimmerová M, Guery BP, Faure K.
Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands.
Infect Immun, 2009, 77:2065-2075.

Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, Secher T, Lacas-Gervais S, Gratadoux JJ, Lafont F, Dagorn JC, Ryffel B, Akira S, Langella P, Nùñez G, Sirard JC, Iovanna J, Simonet M, Chamaillard M.
Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.
Gut, 2009, 58:771-776.

Estrella C, Rocks N, Paulissen G, Quesada-Calvo F, Noël A, Vilain E, Lassalle P, Tillie-Leblond I, Cataldo D, Gosset P.
Role of A disintegrin and metalloprotease-12 in neutrophil recruitment induced by airway epithelium.
Am J Respir Cell Mol Biol, 2009, 41:449-458.

Galperine T, Flateau C, Venon MD, Lescure FX, Béraud G, Said Ibrahim T, Delisle F, Durand F, Faure K, Pialoux G, Guery B.
Recurrent bacteremia, a complication of cyanoacrylate injection for variceal bleeding: report of two cases and review of the literature.
Case Report Med, 2009, 407053.

Ganter MT, Roux J, Su G, Lynch SV, Deutschman CS, Weiss YG, Christiaans SC, Myazawa B, Kipnis E, Wiener-Kronish JP, Howard M, Pittet JF.
Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability.
Am J Respir Cell Mol Biol, 2009, 40:108-118.

Janot L, Sirard JC, Secher T, Noulin N, Fick L, Akira S, Uematsu S, Didierlaurent A, Hussell T, Ryffel B, Erard F.
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
Eur J Immunol, 2009, 39:1587-1596.

Moreau C, Gosset P, Brunaud-Danel V, Lassalle P, Degonne B, Destee A, Defebvre L, Devos D.
CSF profiles of angiogenic and inflammatory factors depend on the respiratory status of ALS patients.
Amyotroph Lateral Scler, 2009, 10:175-181.

Paget, C., Bialecki, E., Fontaine, J., vendeville, C., Mallevaey, T., Faveeuw, C and Trottein, F.
Role of invariant Natural Killer T cells in immune responses to CpG oligonucleotides.
J Immuno, 2009, 182:1846-1853.

Sirard JC, Didierlaurent A, Cayet D, Sierro F, Rumbo M.
Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics.
Biochim Biophys Acta, 2009, 1789:386-394.

Taront S, Dieudonné A, Blanchard S, Jeannin P, Lassalle P, Delneste Y, Gosset P.
Implication of scavenger receptors in the interactions between diesel exhaust particles and immature or mature dendritic cells.
Part Fibre Toxicol, 2009, 13:6-9.

Trottein F, Schaffer L, Ivanov S, Paget C, Vendeville C, Cazet A, Groux-Degroote S, Lee S, Krzewinski-Recchi MA, Faveeuw C, Head SR, Gosset P, Delannoy P.
Differential glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages.
Glycoconjugate J, 2009, 26:1259-1274.

 

2008
Ader F, Faure K, Guery BP, Nseir S.
Pseudomonas aeruginosa and Candida albicans interaction in the respiratory tract: From pathophysiology to a therapeutic perspective.
Pathol Biol (Paris), 2008, 56:164.

Ader F, Le Berre R, Fackeure R, Raze D, Menozzi FD, Viget N, Faure K, Kipnis E, Guery BP, Jarraud S, Etienne J, Chidiac C.
In vivo effect of adhesion inhibitor heparin on Legionella pneumophila pathogenesis in a murine pneumonia model.
Intensive Care Med, 2008, Mar 26.

Depontieu F, Grigoriu BD, Scherpereel A, Adam E, Delehedde M, Gosset P, Lassalle P.
Loss of Endocan tumorigenic properties after alternative splicing of exon 2.
BMC Cancer, 2008, 8:14.

Didierlaurent A, Goulding J, Patel S, Snelgrove R, Low L, Bebien M, Lawrence T, van Rijt LS, Lambrecht BN, Sirard JC, Hussell T.
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.
J Exp Med, 2008, 205:323.

Faveeuw, C., Mallevaey, T, and Trottein, F.
Role of Natural Killer T lymphocytes during helminth infections.
Parasite, 2008, 15:284-288.

Guery BP, Guidet B, Beloucif S, Floret D, Le Gall C, Chouaid C, Jarreau PH, Régnier B.
The organisation of intensive care in a situation of pandemic avian influenza.
Rev Mal Respir, 2008, 25:223.

Henry E, Desmet CJ, Garzé V, Fiévez L, Bedoret D, Heirman C, Faisca P, Jaspar FJ, Gosset P, Jacquet AP, Desmecht D, Thielemans K, Lekeux P, Moser M, Bureau F.
Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma.
J Immunol, 2008, 181:7230-7242.

Kipnis E, Hansen K, Sawa T, Moriyama K, Zurawel A, Ishizaka A, Wiener-Kronish J.
Proteomic analysis of undiluted lung epithelial lining fluid.
Chest, 2008,134:338-345.

Le Berre R, Nguyen S, Nowak E, Kipnis E, Pierre M, Ader F, Courcol R, Guery BP, Faure K. Pyopneumagen Group.
Quorum-sensing activity and related virulence factor expression in clinically pathogenic isolates of Pseudomonas aeruginosa.
Clin Microbio Infect, 2008, 14:337.

Mokart D, Kipnis E, Guerre-Berthelot P, Vey N, Brun JP, Blache JL, Mege JL, Blaise D, Guery BP.
Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor.
Crit Care, 2008, 12:R17.

Nempont C, Cayet D, Rumbo M, Bompard C, Villeret V, Sirard JC.
Deletion of Flagellin’s Hypervariable Region Abrogates Antibodymediated neutralization and systemic activation of TLR5-dependent immunity.
J Immunol, 2008, 181:2036.

Rocks N, Estrella C, Paulissen G, Quesada-Calvo F, Gilles C, Guéders MM, Crahay C, Foidart JM, Gosset P, Noel A, Cataldo DD.
The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis.
Cell Prolif, 2008, 41:988-1001.

Roumier T, Capron M, Dombrowicz D, and Faveeuw C.
Pathogen induced regulatory cell populations preventing allergy through the Th1/Th2 paradigm point of view.
Immunol Res, 2008, 40:1.

Tillie-Leblond I, J de Blic, F Jaubert, B Wallaert, P Scheinmann, P Gosset.
Airway Remodeling is correlated with obstruction in children with severe asthma.
Allergy, 2008, 63:533.

Torres D, Paget C, Fontaine J, Mallevaey T, Matsuoka T, Maruyama T, Narumiya S, Capron M, Gosset P, Faveeuw C, and Trottein F.
Prostaglandin D2 Inhibits the Production of IFN-{gamma} by Invariant NK T Cells : Consequences in the Control of B16 Melanoma.
J Immunol, 2008, 180:783.

Vanhoutte F, Breuilh L, Paget C, Fontaine J, Goriely S, Ryffel B and Trottein F.
Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells.
Immunol Lett, 2008, 116:86.

 

2007
Ader F, Le Berre R, Lancel S, Faure K, Viget NB, Nowak E, Neviere R, Guery BP.
Inhaled nitric oxide increases endothelial permeability in Pseudomonas aeruginosa pneumonia.
Intensive Care Med, 2007, 33:503-510.

Breuilh L, Vanhoutte F, Fontaine J, van Stijn CM, Tillie-Leblond I, Capron M, Faveeuw C, Jouault T, van Die I, Gosset P, Trottein F.
Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cells.
Infect Immun, 2007, 75:5148-5157.

Foligne B, Zoumpopoulou G, Dewulf J, Chareyre F, Sirard JC, Pot B, Grangette. C.
A key role of dendritic cells in probiotic functionality.
PLoS ONE, 2007, 2:e313.

Gosset P, Tillie-Leblond I, Le Berre R, Janin A, Prangère T, Tonnel AB, Guery BP.
KGF improves lung permeability increase and epithelium alterations in allergic rats.
Eur Respir J, 2007, 30:31-39.

Guo A, M. Lasaro A, Sirard JC, Kraehenbuhl JP, Schifferli DM.
Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.
Microbiology, 2007, 153:1059-1069.

Hammad A, Kool M, Soullié T, Narumiya S, Trottein F, Hoogsteden Lambrecht B.
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory cells.
J Exp Med, 2007, 204: 357-367.

Hatzfeld-Charbonnier AS, Lasek A, Gosset P, Velu T, Formstecher P, Mortier L, Marchetti P.
Influence of heat stress on human monocyte-derived dendritic cell functions with immunotherapeutic potential for antitumor vaccines.
J, Leukoc, Biol, 81:1179-1187.

Just N, Moreau C, Lassalle P, Gosset P, Perez T, Wallaert B, Destee A, Defebvre L, Tonnel AB, Devos D.
High erythropoietin and low vascular endothelial growth factor levels in cerebrospinal fluid from hypoxemic ALS patients suggest an abnormal response to hypoxia.
Neuromuscul. Disord, 2007, 17:169-173.

Kipnis E, Guery BP.
Targeting lung coagulation disorders in acute lung injury : easy as pie (PAI-1) ?
Crit Care Med, 2007, 35:1448-1449.

Kipnis E, Guery BP, Wiener-Kronish J.
Promises and limitations of the bronchoscopic microsampling probe.
Chest, 2007, 132:1414.

Mallevaey T, Fontaine J, Breuilh L, Paget C, Vendeville C, Castro- Keller A, Capron M, Leite de Moraes M, Trottein F, Faveeuw C.
Invariant and non-invariant Natural Killer T cells exert opposite regulatory function the immune response during murine schistosomiasis.
Infect Immun, 2007, 75:2171-2180.

Michel ML, Castro-Keller A, Paget C, Trottein F, Schneider E, Dy M, Leite de Moraes M.
Identification of a new IL-17-producing iNKT cell subset involved in airway neutrophilia.
J Exp Med, 2007, 204:995-1001.

Molle C, Nguyen M, Flamand V, Trottein F, Willems F, Goldman M and Goriely S.
IL-27 Synthesis Induced by TLR Ligation Critically Depends on IFN Regulatory Factor 3.
J Immunol, 2007, 178:7607-7615.

Paget C, Mallevaey T, Speak AO, Torres D, Fontaine J, Sheehan KC, Capron M, Ryffel B, Faveeuw F, Leite de Moraes M, Platt F, Trottein F.
Activation of iNKT cells by TLR9-stimulated myeloid dendritic cells requires type I interferon and charged glycosphingolipids.
Immunity, 2007, 27:597-609.

Pierre M, Husson MO, Leberre R, Desseyn JL, Galabert C, Beghin L, Beermann C, Dagenais A, Berthiaume Y, Cardinaud B, Barbry P, Gottrand F, Guery BP.
Omega 3 polyunsaturated fatty acids improve host response in chronic Pseudomonas aeruginosa lung infection in mice.
Am J Physiol Lung Cell Mol Physiol, 2007, 292:1422-1431.

Sirard JC, Vignal C, Dessein R, Chamaillard M.
Nod-like receptors : cytosolic watchdogs for immunity against pathogens.
PLoS Pathog, 2007, 3:e152.

Speak A, Neville D, Priestman D, Salio M, Platt N, Heare T, Butters TD, Dwek RA, Trottein F, Exley M, Cerundolo V, Platt F.
Restricted presence of isoglobotrihexosylceramide in mammals : implications for the identity of NKT cell ligands.
Proc Natl Acad Sci USA, 2007, 104:5971-5976.

Tetaert D, Pierre M, Demeyer D, Husson MO, Béghin L, Galabert C, Gottrand F, Beermann C, Guery BP, Desseyn JL.
Dietary n-3 fatty acids have suppressive effects on mucin upregulation in mice infected with Pseudomonas aeruginosa.
Respir Res, 2007, 5:39.

Tillie-Leblond I, Gosset P, Le Berre R, Janin A, Prangère T, Tonnel AB, Guery BP.
Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats.
Eur Respir J, 2007, 30:31-39.

Vanhoutte F, Breuilh L, Fontaine J, Zouain C, Mallevaey T, Vasseur V, Capron M, Goriely S, Faveeuw F, Ryffel B, Trottein F.
Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology.
Microbes Infect, 2007, 9:1606-1613.

Wesley JD, Tessmer MS, Paget C, Trottein F and Brossay L.
A Y-chromosome linked factor impairs iNK T development.
J Immunol, 2007, 179:3480-3487.

 

PhD
François VANHOUTTE
Directeur de thèse : F. Trottein
"Rôle des récepteurs Toll-like dans les interactions hôte/schistosome"
Université Lille 2. Discipline Immunologie
15 Juin 2007.

Laetitia BREUILH
Directeur de thèse : I. Tillie-Leblond
"Rôle des récepteurs Toll-like et des récepteurs lectiniques dans la réponse immune de type 2 : modèle de la schistosomiase"
Université Lille 2. Discipline Immunologie
8 Octobre 2007.

Rozen LEBERRE
Directeur de thèse : B. Guery
"Physiopathologie et rôle des facteurs de virulence dans la pneumonie à Pseudomonas aeruginosa".
Université de Marseille
15 Octobre 2007.

Eric KIPNIS
Directeur de thèse : B. Guery
"Place du SST III dans l’atteinte infectieuse".
Université Lille 2. Sciences de la vie et de la santé
13 Décembre 2007

Solenne TARONT
Directeur de thèse : P. Gosset
"Impact des motifs bactériens et des particules de diesel sur les interactions épithélium bronchique / cellules dendritiques"
Université Lille 2. Discipline Immunologie
3 Octobre 2008.

 

Patents
Sirard JC
Novel immunoadjuvant flagellin-based compounds and use thereof
25 juin 2008 – EP n°08 305 327.2, 23 juin 2009 - PCT/EP2009/057836, 30 décembre 2009 - WO2009/156405.